EBNA1: Epstein-Barr virus Nuclear Antigen 1

EBNA1 is a multifunctional protein essential for EBV survival during latency. It is involved in gene regulation, extrachromosomal replication, and maintenance of the episomal genome, which occurs through binding to specific sites at the origin of viral replication.  During latency, EBNA1 promotes cell transformation, proliferation, and resistance to apoptosis.  EBNA1 is the only EBV protein expressed in all EBV-related malignancies. 

In collaboration with the Wellcome Trust and NIH, we have identified multiple small molecule inhibitors of EBNA1.  Our lead product candidate, VK-2019, is currently in clinical development.